Nephrogenic Diabetes Insipidus Treatment Thiazide

Thiazides can be used to paradoxically decrease urine flow in people with nephrogenic diabetes insipidus.

Nephrogenic diabetes insipidus treatment thiazide. The principal indications for the use of thiazides are i oedematous states and ii hypertension of patients with preserved renal function. In infants with hereditary nephrogenic di treatment is aimed at minimizing the polyuria and avoiding hypernatremia and volume depletion. While these results are specific to li induced renal effects they may at least partially explain how a thiazide can serve to decrease polyuria in patients with diabetes insipidus. Nephrogenic di may be treated by addressing the underlying cause or the use of a thiazide aspirin or ibuprofen.

Some treatments can reduce the symptoms of nephrogenic diabetes insipidus at least somewhat. The clinical use of thiazides in nephrogenic diabetes insipidus. The number of new cases of diabetes insipidus each year is 3 in 100 000. 0 25 mg h for 3 h in rats with nephrogenic diabetes insipidus ndi was investigated.

Nonsteroidal anti inflammatory drugs nsaids like ibuprofen motrin indomethacin indocin and naproxen. In rates with lithium induced nephrogenic di hctz reversed lithium induced downregulation of aqp2. The mechanisms underlying the acute antidiuretic response to bendroflumethiazide bftz. A low salt low protein diet reduces urine output.

Listing a study does not mean it has been evaluated by the u s. In adults therapy is usually aimed at correcting the underlying disorder or discontinuing an offending drug. Central di usually starts between the ages of 10 and 20 and occurs in males and females equally. Atorvastatin for the treatment of lithium induced nephrogenic diabetes insipidus the safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Calcium balance edit. Thiazides may also be useful in treating hyponatremia low blood sodium in infants with central diabetes insipidus. Ancillary indications are hypercalciuria nephrolithiasis and nephrogenic diabetes insipidus ndi. Ndi was induced in conscious chronically instrumented female wistar rats either by chronic lithium administration 40 60 mmol.